Synthesis, Characterization and Activity

Synthesis, Characterization, and Activity of SOD Mimetics

Presenter: Chase Clark

Co-Presenter(s):
David Wycoff

Presenter Status: Undergraduate student

Department: Chemistry

Screenshot URL: https://drive.google.com/uc?id=1oteZ5SWkbtwJiFXhwXeBoFmD293mrrRD

Abstract:

Endogenous enzymes known as SODs exist to convert superoxide anions into hydrogen peroxide which is then converted to water and carbon dioxide by catalse. When not enough endogenous enzymes are present oxidative stress occurs, which can lead to a variety of tissue damage. SOD mimetics made from salen and coordinating metals have been shown to exhibit both SOD and catalase activity, therefore they can be utilized as therapeutics against oxidative stress. For this project, the synthesis and characterization of two published salen manganese mimetics is carried out and the SOD and catalase activity of each is tested. A third mimetic based on the findings of prior research is developed and its activity is tested as well to see if it serves as a competent mimetic.