Synthesis of Carbazole Derivatives

Presenter: Vanessa Reyes

Co-Presenter(s):
Lily Harmon

Presenter Status: Undergraduate student

Academic Year: 22-23

Semester: Spring

Faculty Mentor: Steven Farmer

Department: Chemistry

Funding Source/Sponsor: McNair

Abstract:
This research focuses on creating accessible pathways to Carbazole Derivatives from attainable reagents while using Sulfur Extrusion Route as the final step. Carbazole is found to have medicinal properties and has the potential to advance medicinal chemistry and pharmaceuticals. Yet, the formation of Carbazole can be tricky and tend to have low yields. Dr. David E. Olson at UC Davis inspired this project with his work exploring a non-hallucinogenic psychedelic to increase neuroplasticity without the risks of drug-related trauma. Among the known hallucinogens is a carbazole derivative called harmine, which an organic chemist could customize to alter its effects on the brain. In the current body of knowledge, there are only a few ways to make carbazole derivatives and no generalized synthetic pathway. Through this research, we will be working on creating an ideal generalized high-yielding route to carbazole derivatives, with our first target products being Murrayafoline A and α-Carboline. If so, we can apply a three-step synthesis with a sulfur extrusion as the final step to different aniline derivatives and create exciting products that can excel in medicinal chemistry.