Parental Genome Organization
Mechanisms of Parental Genome Organization
Presenter: Breanna Lee
Presenter Status: Undergraduate student
Academic Year: 19-20
Semester: Spring
Faculty Mentor: Lisa Hua
Department: Biology
Funding Source/Sponsor: Koret Scholars Program
Abstract:
| Human embryonic and neonatal cells display a haploid chromosome set (1n) non-randomly organized during mitosis. However, the underlying mechanisms driving this chromosome organization are unknown. A parent of origin mechanism has been proposed for the haploid set organization, where each haploid set is derived from the maternal and paternal genomes. This project will focus on the heterogenic zygotic divisions, specifically during interphase, to better understand whether this parental genome separation is preserved in subsequent divisions. Interphase is an excellent phase to study for the proposed question because it provides a hint at the underlying mechanism of the parental genome segregation observed at mitosis. |