Manganese-Cocatalyst Porphyrin Performing Single Oxygen Transfer

Manganese-Cocatalyst Porphyrin Performing Single Oxygen Transfer into Hydrocarbon Mimicking Monooxygenation of Cytochrome P-450

Presenter: Viviana Reyes

Co-Presenter(s):
Jorge Calderon Moreno

Presenter Status: Undergraduate student

Academic Year: 20-21

Semester: Spring

Faculty Mentor: Jon Fukuto

Department: Chemistry

Funding Source/Sponsor: Class Project

Screenshot URL: https://drive.google.com/uc?id=1kxMLJkEe83-vOQyunE1WmAgYTDNyrqpB

Abstract:
Metalloporphyrin Mn(porphyrin)Cl complexes are poor at catalyzing by themselves in selective oxygen atom insertion from oxygen donors into different organic molecules under mild conditions (2) to work effectively at oxygen atom insertion just as cytochrome P-450 does with a single oxygen atom donor. Cocatalysts serve to increase oxygen atom transfer into hydrocarbons and for Mn(porphyrin)Cl complexes and cocatalyst with nitrogenous bases are most effective in hydrocarbon oxidation with H₂O₂ (3). The goal of the project is to synthesize a Mn-(porphyrin)Cl-H2O2 with nitrogenous base cocatalyst system that is able to mimic monooxygenation of hydrocarbons as cytochrome P-450 carries out and test different nitrogenous based cocatalysts. To determine the effectiveness of the transfer of an oxygen atom from H₂O₂ into hydrocarbons cyclooctane and cyclooctene have been selected in an effort to learn more about the impact of different nitrogenous base cocatalyst on the system to extend Battioni’s group previous work with Mn-(porphyrin)Cl-H2O2 and imidazole.