Cytochrome P450 Mimetic

Cytochrome P450 Mimetic: From a Fluorine Iron(III) Approach

Presenter: Leah Stover

Co-Presenter(s):
Ryan Simmons

Presenter Status: Undergraduate student

Academic Year: 22-23

Semester: Spring

Faculty Mentor: Jon Fukuto

Department: Chemistry

Funding Source/Sponsor: Class Project

Screenshot URL: https://drive.google.com/uc?id=14PgvEZx0u0brGUGybJl2Dres32naXFuI

Abstract:
Cytochrome P450 is part of a superfamily of enzymes containing heme as a prosthetic group or cofactor that function as monooxygenases in many oxidation reactions, including the production of steroids, fatty acids, and xenobiotics as well as hormone synthesis. The reactions of this mechanism is well known, but there is not a full synthesis for the process on how sulfides are oxidized. In this research, we synthesized a CYP450 mimetic and studied the turnover number (TON) of the catalyst.