Cytochrome P450 Mimetic: From a Fluorine Iron(III) Approach
Presenter
:
Leah Stover
Co-Presenter(s)
:
Ryan Simmons
Presenter Status
:
Undergraduate student
Academic Year
:
22-23
Semester
:
Spring
Faculty Mentor
:
Jon Fukuto
Department
:
Chemistry
Funding Source/Program
:
Class Project
Abstract
:
Cytochrome P450 is part of a superfamily of enzymes containing heme as a prosthetic group or cofactor that function as monooxygenases in many oxidation reactions, including the production of steroids, fatty acids, and xenobiotics as well as hormone synthesis. The reactions of this mechanism is well known, but there is not a full synthesis for the process on how sulfides are oxidized. In this research, we synthesized a CYP450 mimetic and studied the turnover number (TON) of the catalyst.